The four cycles any drug goes through in the body are absorption, distribution, metabolism and elimination. Any combination of drugs as well as certain herbs can result in either a pharmacokinetic or a pharmacodynamic interaction at any of these four stages. Such interactions are very difficult to study, because it is not simply the combination of two compounds that can lead to an interaction but also the timing, concentration or even the preparation of the food or the compound that can result in an interaction. Genetic factors can also contribute as certain people may act on herbs differently when they are taken into the body.
One risk of drug interactions is perhaps if ingested together with alcohol, they lose their effectiveness. Not only will you not be getting better, but often you will become sicker with nausea, vomiting, headaches, shortness of breath and possibly convulsions. It isn't just alcohol that should be avoided while taking Rhodiola herb. Sometimes you have to avoid milk also. This specific is definitely legitimate of the tetracycline types of prescription.
Among the types of drugs known to have interactions with the Rhodiola herb are anti-seizure medications, antidepressants, tranquilizers and calcium channel blockers. Some reports conclude that this interaction only occurs if the Rhodiola herb is consumed at the same time as the drug. Consuming the Rhodiola herb well before or well after the consumption the drug may not cause an interaction. Because the chemical involved in this interaction is unknown, this risk is associated with whole Rhodiola herb leaves, Rhodiola herb roots and even Rhodiola herb powder.
When combined with diabetes medication Rhodiola herb can cause a dangerous decrease in blood sugar levels. Large doses can also thin the blood and in effect amplify the effects of blood thinning drugs like warfare and aspirin or other blood thinners.
Rhodiola herb is contraindicated during pregnancy-especially in the first trimester-because of the effects of anthraquinone glycosides found in the roots of Rhodiola herb plants. It is also contraindicated in patients who are hypersensitive to the herb or related plant species.
Be Alert of herb interactions that results to Poisoning caused by atropine contamination of some commercial Rhodiola herbs can occur. Signs and symptoms of toxicity include blurred vision, dilated pupils, and rapid pulse rate. Treatment of this, if needed, includes physostigmine reversal.
Combinations of individual nutrients can also lead to interactions. When combined with iron and Rhodiola herb, zinc absorption can be reduced or the zinc can reduce the absorption of the iron and the Rhodiola herb. The effects of this type of interaction can take days, weeks or even months to display, making it very difficult to diagnose
Another drug interaction with a very common food involves using the herb with the grapefruit. Containing many nutrients including vitamin C and a long list of phytochemicals, an unidentified phytochemicals in grapefruit leads to a Pharmacodynamic interaction that amplifies be a fact of certain drugs and therefore increases the risk of drug toxicity as well as drug side effects.